Seeded 14th, the Rams (8-2) defeated the 19th-seeded Broncos(6-5) with a final score of 63-42.
The Broncos' defense struggled against 510 yards from the Rams' offensive line.
Conversely, Zachary put up 463 yards passing with QB Trey Hills at the helm.
Acadiana took a 14-0 lead in the first-quarter, but the Broncos scored two touchdowns tying the game.
Going into the half, the Rams led 28-21, and in the third-quarter, the momentum changed.
The Broncos scored only one TD to three by the Rams, making the score 49-35.
It still seemed as if Zachary had a chance, but in the fourth Acadiana scored two more touchdowns to Zachary's one making it a final score of 63-42.
Acadiana meets West Monroe in the regional round of the state playoffs.
Bi-district play results for area teams from Nov. 9:
• Ponchatoula 28
Central 52 (will play Mandeville in regionals)
• Carencro 42
Catholic-BR F/OT (will play New Iberia in the regionals)
• Scotlandville 8
New Iberia 13 (will play Catholic in the regionals)
• Denham Springs 14
West Monroe 31 (will play Acadiana in regionals)
• Erath 14
Parkview 45 (plays Brusly in regionals)
• East Feliciana 22 (plays Rayne in regionals)
• West Feliciana 22
North DeSoto 49 (plays Jewel Sumner in regionals)
Springfield 24 (plays Northlake Christian in regionals)
• Catholic-PC 7
Southern Lab 40 (plays Pointe Coupee Central in regionals)
• Montgomery 18
Pointe Coupee Central 52 (plays Southern Lab in regionals)